Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement
Escherichia coli — E. coli
Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 10 November 2026 · Methodology
Enterobacteriaceae · Gram-negative
Cause la plus fréquente de bactériémie (Laupland 2008, région de Calgary : 30,3/100 000 habitants/an). Tropisme essentiellement uro-digestif. L'endocardite à E. coli est une entité EXCEPTIONNELLE (<1% des EI — ICE-PCS 2009), qu'aucune recommandation ne retient comme indication d'ETT/ETO de principe (ESC 2023, IDSA, SPILF). L'ETT/ETO ne se justifie QUE si facteurs de risque spécifiques : valvulopathie connue, matériel prothétique, bactériémie prolongée ou récidivante, signes d'EI clinique. BLSE : SPILF 2015 réserve les carbapénèmes aux situations sans alternative (fluoroquinolone, TMP-SMX, puis bêta-lactamine selon CMI en priorité).
Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.
Documented organ tropism
Organs where foci of Escherichia coli are described in the cited literature. The reported frequency is not an individual probability.
| Organ | Tropism | Level of evidence | Sources | Spread route |
|---|
| Urinary system / Bladder |
High tropism |
Evidence B |
5 |
not recorded |
| Kidney |
High tropism |
Evidence B |
3 |
not recorded |
| Liver / Bile duct |
High tropism |
Evidence B |
2 |
not recorded |
| Colon / Alimentary system |
Moderate tropism |
Evidence B |
3 |
not recorded |
| Lung |
Rare tropism |
Evidence B |
2 |
not recorded |
| Bones / Joints |
Rare tropism |
Evidence B |
1 |
not recorded |
| Meninges |
Rare tropism |
Evidence B |
4 |
not recorded |
| Skin |
Rare tropism |
Evidence B |
1 |
not recorded |
| Prostate |
High tropism |
Evidence B |
3 |
direct |
| Gallbladder |
Moderate tropism |
Evidence B |
1 |
direct |
Described portals of entry
- Urinary system / Bladder
- Colon / Alimentary system
Described spread path
Flore intestinale → muqueuse digestive/urinaire → vaisseau → bactériémie → rein, foie, voies biliaires, méninges (néonatal)
Spread routes recorded: 2 of 10 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.
Associated syndromes
Sources
- SPILF — Diagnostic et antibiothérapie des infections urinaires bactériennes communautaires de l'adulte (actualisation 2015) (2015) — https://www.infectiologie.com/UserFiles/File/spilf/recos/infections-urinaires-spilf.pdf
- Laupland KB et al. — Incidence, risk factors and outcomes of Escherichia coli bloodstream infections (2008) — doi:10.1111/j.1469-0691.2008.02089.x
- Wagenlehner FME et al. — Epidemiology, definition and treatment of complicated urinary tract infections (2020) — doi:10.1038/s41585-020-0362-4
- EAU — Guidelines on Urological Infections (Bonkat G et al.) (2020) — https://uroweb.org/guidelines/urological-infections
- Santé publique France / Mission PRIMO — Surveillance de la résistance bactérienne aux antibiotiques en soins de ville et en Ehpad, résultats 2024 (avril 2026) (2026)
- IDSA — Diagnosis, Prevention and Treatment of Catheter-Associated UTI (CID) (2010) — doi:10.1086/650482
- Kiriyama S et al. — Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (J Hepatobiliary Pancreat Sci) (2018) — doi:10.1002/jhbp.512
- Gomi H et al. — Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis (J Hepatobiliary Pancreat Sci) (2018) — doi:10.1002/jhbp.518
- IDSA — Intra-abdominal Infections Guidelines (2010) — doi:10.1086/649554
- Mazuski JE et al. — The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection (Surg Infect) (2017) — doi:10.1089/sur.2016.261
- Restrepo MI & Anzueto A — The role of Gram-negative bacteria in healthcare-associated pneumonia (Semin Respir Crit Care Med) (2009) — doi:10.1055/s-0028-1119810
- Kalil AC et al. — IDSA/ATS Management of Adults with HAP/VAP (2016) — doi:10.1093/cid/ciw353
- Berbari EF et al. — IDSA Clinical Practice Guidelines for Native Vertebral Osteomyelitis (2015) — doi:10.1093/cid/civ482
- Kim KS — Acute bacterial meningitis in infants and children (Lancet Infect Dis) (2010) — doi:10.1016/S1473-3099(09)70306-8
- SPILF — Info-antibio n° 90 (août 2019) : Méningites bactériennes communautaires, recommandations 2018 (synthèse) (2019) — https://www.infectiologie.com/UserFiles/File/spilf/atb/info-antibio/info-antibio-2019-08-meningite.pdf
- SPILF — Prise en charge des méningites bactériennes aiguës communautaires (à l'exclusion du nouveau-né) : version longue avec argumentaire (Hoen B et al., Méd Mal Infect) (2019) — doi:10.1016/j.medmal.2019.03.009
- SPILF — Prise en charge des méningites aiguës communautaires : actualisation 2018 des recommandations (X. Duval, 19es JNI, Nantes, juin 2018), diaporama (2018) — https://www.infectiologie.com/UserFiles/File/jni/2018/com/jni2018-reco-meningite-x-duval.pdf
- Lipsky BA et al. — IDSA Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infections (CID) (2012) — doi:10.1093/cid/cis346
- Lipsky BA et al. — Treatment of bacterial prostatitis (CID) (2010) — doi:10.1086/652861
- SPILF — Infections urinaires masculines : antibiothérapie, recommandation SPILF 2026 (Info-antibio n° 109, juin 2026, version provisoire) (2026) — https://www.infectiologie.com/UserFiles/File/spilf/atb/info-antibio/info-antibio-2026-06-ium.pdf
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