Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Pseudomonas aeruginosa

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 30 October 2026 · Methodology

Pseudomonadaceae · Gram-negative

Bactérie opportuniste quasi-exclusive des patients fragilisés : mucoviscidose, immunodépression profonde (neutropénie <500/mm³), brûlés, réanimation sous VM. L'ecthyma gangrenosum est une lésion cutanée évocatrice de bactériémie à Pseudomonas chez le neutropénique (urgence thérapeutique). Bithérapie (2 molécules actives) suggérée en cas de choc septique ou de risque élevé de décès ; sinon monothérapie recommandée une fois l'antibiogramme connu (Kalil 2016, PAH/PAVM).

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Pseudomonas aeruginosa are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Lung	High tropism	Evidence B	2	not recorded
Skin (ecthyma gangrenosum)	High tropism	Evidence B	1	not recorded
Bones / Joints	Moderate tropism	Evidence C	1	not recorded
Heart / Endocardium	Rare tropism	Evidence B	1	not recorded
Urinary system / Bladder	Moderate tropism	Evidence B	1	not recorded
Pleura	Moderate tropism	Evidence B	2	contiguous
Ear — Otite externe maligne	High tropism	Evidence C	1	direct

Described portals of entry

• Lung
• Skin
• Urinary system / Bladder

Spread routes recorded: 2 of 7 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Associated syndromes

• Community-acquired pneumonia (CAP)
• Urinary tract infection (UTI) (cystitis / pyelonephritis)
• Bacterial skin infections
• Septic arthritis and osteomyelitis
• Bacteraemia and sepsis
• Prosthesis-related infection
• Cholecystitis and cholangitis

Sources

• Cystic Fibrosis Foundation — Patient Registry, 2022 Annual Data Report (2022) — https://www.cff.org/medical-professionals/patient-registry
• Kalil AC et al. — IDSA/ATS Management of Adults with HAP/VAP (2016) — doi:10.1093/cid/ciw353
• Bodey GP et al. — Pseudomonas bacteremia: retrospective analysis of 410 episodes (Arch Intern Med) (1985) — doi:10.1001/archinte.1985.00360090089015
• Lew DP & Waldvogel FA — Osteomyelitis (Lancet) (2004) — doi:10.1016/S0140-6736(04)16727-5
• ESC Guidelines for the management of endocarditis (Delgado V et al.) (2023) — doi:10.1093/eurheartj/ehad193
• EAU — Guidelines on Urological Infections (Bonkat G et al.) (2020) — https://uroweb.org/guidelines/urological-infections
• Mandell LA et al. — IDSA/ATS CAP Consensus Guidelines (CID) (2007) — doi:10.1086/511159
• Metlay JP et al. — Diagnosis and Treatment of Adults with Community-acquired Pneumonia: ATS/IDSA Clinical Practice Guideline (Am J Respir Crit Care Med) (2019) — doi:10.1164/rccm.201908-1581ST
• Carfrae MJ & Kesser BW — Malignant otitis externa (review) (2008) — doi:10.1016/j.otc.2008.01.004

This page is the text version, generated at build time. The 3D anatomical atlas requires JavaScript.