Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Diagram — PK/PD: time, peak and area under the curve — SeptiMap

link each class to its efficacy index (T > MIC, Cmax/MIC, AUC/MIC) and derive the principle of its administration, without doses. Educational resource, not a medical device.

Diagrams: mechanisms and principles

17 sourced diagrams · for medical students and practice

Each diagram reads step by step: an objective, the steps, three key points, a classic pitfall, its sources and the related atlas pages. Revision mode hides the labels to test yourself.

Clinical years · residency

PK/PD: time, peak and area under the curve

Objective: link each class to its efficacy index (T > MIC, Cmax/MIC, AUC/MIC) and derive the principle of its administration, without doses.

Step 4 / 4
PK/PD: time, peak and area under the curve1. Time-dependent — For β-lactams, efficacy depends on the time spent above the MIC (T > MIC). 2. Concentration-dependent — Aminoglycosides and fluoroquinolones: drug amount relative to the MIC matters (Cmax/MIC and AUC/MIC), with a post-antibiotic effect. 3. Area under the curve — AUC/MIC is the vancomycin index; it is also the main index for fluoroquinolones. 4. Principle — β-lactams: frequent dosing or prolonged infusion; aminoglycosides: once-daily dosing. The exact regimen belongs to the guidelines.ConcentrationTimeMICT > MICβ-lactams: time-dependent,time above the MIC mattersCmax (peak)Aminoglycosides, fluoroquinolones:concentration-dependent (Cmax, AUC)AUCVancomycin: AUC/MIC;fluoroquinolones mainly AUC/MICPrinciples, not doses:dosing belongs to the guidelines.
  • Antibiotic
  • Toxin, damage
  • Structure

Key points

  • β-lactams: time-dependent, keep the concentration above the MIC.
  • Aminoglycosides, fluoroquinolones: concentration-dependent, post-antibiotic effect.
  • Vancomycin: AUC/MIC index.

Classic pitfall

Thinking that raising a β-lactam concentration speeds killing in proportion: time above the MIC is what matters.

Sources

Educational content · Illustrative mechanisms · Not applicable to individual clinical decisions · MDR 2017/745

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