Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Diagram — Immune deficits and pathogens — SeptiMap

match each immune deficit with the pathogens it exposes, and open their pages. Educational resource, not a medical device.

Diagrams: mechanisms and principles

17 sourced diagrams · for medical students and practice

Each diagram reads step by step: an objective, the steps, three key points, a classic pitfall, its sources and the related atlas pages. Revision mode hides the labels to test yourself.

Clinical years · all specialties

Immune deficits and pathogens

Objective: match each immune deficit with the pathogens it exposes, and open their pages.

Step 5 / 5
Immune deficits and pathogens1. Neutropenia — Gram-negative rods including Pseudomonas, Gram-positive cocci, and Candida and Aspergillus, all the more when neutropenia is deep and prolonged. 2. Asplenia — Encapsulated bacteria, mainly pneumococcus, meningococcus and H. influenzae b; Capnocytophaga canimorsus after a dog bite. 3. Cell-mediated immune defect — Pneumocystis, mycobacteria, Listeria, Nocardia, Toxoplasma, Cryptococcus and herpes-group viruses. 4. Antibody deficiency — Recurrent sinus and lung infections, mainly with encapsulated bacteria. 5. Terminal complement — A C5–C9 deficiency predisposes almost exclusively to invasive meningococcal infection, often recurrent.NeutropeniaGram-negative rods incl. Pseudomonas,Gram + cocci, Candida, AspergillusAspleniaEncapsulated: mainly pneumococcus,meningococcus, Hib; CapnocytophagaCell-mediated (T-cell) defectPneumocystis, mycobacteria, Listeria,Nocardia, Toxoplasma, Cryptococcus,herpes-group virusesAntibody deficiencyEncapsulated bacteria: recurrentsinus and lung infectionsComplement C5 to C9 deficiencyMeningococcus, recurrent infections
  • Immunity
  • Pathogen

Key points

  • Neutropenia: Gram-negative rods, Gram-positive cocci, Candida, Aspergillus.
  • Asplenia and antibody deficiency: encapsulated bacteria, pneumococcus first.
  • T-cell defect: intracellular and opportunistic agents; terminal complement: meningococcus.

Classic pitfall

Failing to consider complement in recurrent meningococcal disease: terminal-pathway deficits predispose almost exclusively to it.

Atlas pages by deficit (sources often name a group, such as “Gram-positive cocci”, not a species: the link to a page is indicative).
DeficitPages
Neutropenia
Asplenia
T-cell defect
Antibodies
Complement C5–C9

Sources

Educational content · Illustrative mechanisms · Not applicable to individual clinical decisions · MDR 2017/745

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