Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Klebsiella pneumoniae — Klebsiella

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 29 October 2026 · Methodology

Enterobacteriaceae · Gram-negative

Klebsiella pneumoniae est une cause importante d'abcès hépatiques (notamment la forme hypervirulente en Asie du Sud-Est — syndrome de Klebsiella hypervirulent avec atteintes métastatiques oculaires et SNC). Les EPC (entérobactéries productrices de carbapénémases) sont à signaler aux autorités sanitaires. En cas de bactériémie, la recherche d'un abcès hépatique ou pulmonaire est décrite comme de principe.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Klebsiella pneumoniae are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Lung	High tropism	Evidence B	1	not recorded
Liver / Bile duct (abcès hépatique)	High tropism	Evidence B	2	not recorded
Urinary system / Bladder	High tropism	Evidence B	2	not recorded
Meninges	Moderate tropism	Evidence B	2	hematogenous
Eye	Moderate tropism	Evidence C	1	hematogenous
Gallbladder	High tropism	Evidence B	2	direct

Described portals of entry

• Urinary system / Bladder
• Lung
• Colon / Alimentary system

Described spread path

Flore digestive (portage) → voie endogène (urinaire, pulmonaire) OU voie hématogène → foie (abcès), poumon, méninges (K. hypervirulente)

Spread routes recorded: 3 of 6 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Associated syndromes

• Community-acquired pneumonia (CAP)
• Urinary tract infection (UTI) (cystitis / pyelonephritis)
• Bacteraemia and sepsis
• Cholecystitis and cholangitis
• Bacterial peritonitis

Sources

• Mandell LA et al. — IDSA/ATS CAP Consensus Guidelines (CID) (2007) — doi:10.1086/511159
• Siu LK et al. — Klebsiella pneumoniae liver abscess: a new invasive syndrome (2012) — doi:10.1016/S1473-3099(12)70205-0
• Wang JH, Liu YC et al. — Primary liver abscess due to Klebsiella pneumoniae in Taiwan (Clin Infect Dis) (1998) — doi:10.1086/516369
• IDSA UTI Practice Guidelines (2011) — doi:10.1093/cid/ciq257
• EAU — Guidelines on Urological Infections (Bonkat G et al.) (2020) — https://uroweb.org/guidelines/urological-infections
• Lu CH et al. — Klebsiella meningitis in adults: clinical features, prognostic factors and therapeutic outcomes (J Clin Neurosci) (2002) — doi:10.1054/jocn.2001.1032
• Liu YC et al. — Klebsiella pneumoniae liver abscess associated with septic endophthalmitis (Arch Intern Med) (1986) — doi:10.1001/archinte.1986.00360220057011
• Gomi H et al. — Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis (J Hepatobiliary Pancreat Sci) (2018) — doi:10.1002/jhbp.518

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