Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Candida spp. — Invasive candidiasis

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 30 October 2026 · Methodology

Candidaceae · Yeast

Devant une candidémie, l'IDSA 2016 décrit : (1) fond d'œil dilaté dans la première semaine (atteinte oculaire chez jusqu'à 16 % des candidémies — IDSA 2016) ; (2) retrait du cathéter central le plus tôt possible lorsqu'il est la source présumée et que le retrait est sûr ; (3) hémocultures de contrôle jusqu'à négativation ; (4) traitement (duration not verified) après la clairance documentée du sang (première hémoculture négative) et la résolution des symptômes — see cited source. Échinocandine en 1ère ligne (caspofungine, micafungine, anidulafungine — IDSA 2016) ; fluconazole acceptable chez le patient non grave à faible risque de résistance. Fluconazole acceptable si : espèce sensible documentée, patient stable, pas de C. krusei/glabrata. C. auris : espèce émergente multi-résistante, à signaler aux autorités sanitaires.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Candida spp. are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Eye (endophtalmie)	Moderate tropism	Evidence B	3	not recorded
Heart / Endocardium	Moderate tropism	Evidence B	3	not recorded
Kidney	Moderate tropism	Evidence B	2	not recorded
Liver / Bile duct (candidose hépatosplénique)	Moderate tropism	Evidence B	2	hematogenous
Spleen	Moderate tropism	Evidence B	1	hematogenous

Described portals of entry

• Urinary system / Bladder
• Colon / Alimentary system

Spread routes recorded: 2 of 5 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Associated syndromes

• Infective endocarditis (IE)
• Urinary tract infection (UTI) (cystitis / pyelonephritis)
• Bacteraemia and sepsis
• Prosthesis-related infection
• Bacterial peritonitis

Sources

• Pappas PG et al. — IDSA Clinical Practice Guideline for the Management of Candidiasis (2016) — doi:10.1093/cid/civ933
• ESCMID — Guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients (Cornely OA et al., Clin Microbiol Infect) (2012) — doi:10.1111/1469-0691.12039
• Kullberg BJ & Arendrup — Invasive fungal disease (NEJM) (2015) — doi:10.1056/NEJMra1315399
• ESC Guidelines for the management of endocarditis (Delgado V et al.) (2023) — doi:10.1093/eurheartj/ehad193

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