Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Stenotrophomonas maltophilia — Stenotrophomonas

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 29 October 2026 · Methodology

Lysobacteraceae (anc. Xanthomonadaceae) · Gram-negative

Stenotrophomonas maltophilia est résistante INTRINSÈQUEMENT aux carbapénèmes (métallo-bêta-lactamase L1 et céphalosporinase L2) — piège thérapeutique majeur si traitement empirique par carbapénème initié. Bactérie quasi-exclusivement nosocomiale des patients profondément immunodéprimés (neutropénie prolongée, transplantation, mucoviscidose, corticothérapie au long cours) et sous ventilation mécanique. Traitement de référence : triméthoprime-sulfaméthoxazole (TMP-SMX) de TMP IV ou per os (excellente biodisponibilité orale). Alternatives : lévofloxacine, minocycline, céfidérocol (la ticarcilline-clavulanate n'est plus commercialisée). La colonisation respiratoire (fréquente en mucoviscidose) ne justifie pas de traitement de principe.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Stenotrophomonas maltophilia are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Lung (colonisation/pneumopathie)	High tropism	Evidence B	2	not recorded
Skin (CLABSI)	High tropism	Evidence B	2	not recorded
Meninges (méningite nosocomiale)	Rare tropism	Evidence C	1	not recorded
Urinary system / Bladder	Moderate tropism	Evidence C	1	not recorded

Spread routes recorded: 0 of 4 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Sources

• Kalil AC et al. — IDSA/ATS Management of Adults with HAP/VAP (2016) — doi:10.1093/cid/ciw353
• Brooke JS — Stenotrophomonas maltophilia: an emerging global opportunistic pathogen (CMR) (2012) — doi:10.1128/CMR.00019-11
• IDSA — Management of Intravascular Catheter-Related Infections Guidelines (2009) — doi:10.1086/599376

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