Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Staphylococcus epidermidis (CoNS) — Staphylococcus epidermidis

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 30 October 2026 · Methodology

Staphylococcaceae · Gram-positive

1ère cause d'infection associée aux soins sur matériel (cathéter central, prothèse valvulaire, DVP, PTH/PTG). Distinct de S. lugdunensis (déjà dans la base). S. epidermidis : virulence faible mais forme biofilm irradicable sur matériel étranger. SCRM dans la majorité des cas — vancomycine ou daptomycine. Isolé sur hémoculture : évaluer s'il s'agit d'une infection vraie ou d'une contamination (2 hémocultures positives sur sites différents + tableau clinique cohérent). Sur prothèse valvulaire : EI tardive (>1 an) à S. epidermidis = mortalité élevée.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Staphylococcus epidermidis (CoNS) are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Heart / Endocardium — EI sur prothèse valvulaire	High tropism	Evidence B	2	hematogenous
Central nervous system — Ventriculite sur DVP	High tropism	Evidence B	1	direct
Bones / Joints	High tropism	Evidence B	2	direct
Cathéter / Port-à-cath	High tropism	Evidence B	2	direct

Described portals of entry

• Skin

Spread routes recorded: 4 of 4 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Associated syndromes

• Infective endocarditis (IE)
• Prosthesis-related infection

Sources

• ESC Guidelines for the management of endocarditis (Delgado V et al.) (2023) — doi:10.1093/eurheartj/ehad193
• Murdoch DR et al. — Clinical presentation, etiology and outcome of infective endocarditis (ICE-PCS) (2009) — doi:10.1001/archinternmed.2008.603
• Tunkel AR et al. — IDSA Management of Healthcare-Associated Ventriculitis (CID) (2017) — doi:10.1093/cid/ciw861
• Osmon DR et al. — IDSA Diagnosis and Management of Prosthetic Joint Infection (2012) — doi:10.1093/cid/cis803
• HAS — Prothèse de hanche ou de genou : diagnostic et prise en charge de l'infection dans le mois suivant l'implantation (RBP, mars 2014) (2014) — https://www.has-sante.fr/jcms/c_1228574/fr/prothese-de-hanche-ou-de-genou-diagnostic-et-prise-en-charge-de-l-infection-dans-le-mois-suivant-l-implantation
• IDSA — Management of Intravascular Catheter-Related Infections Guidelines (2009) — doi:10.1086/599376
• Becker K et al. — Coagulase-negative staphylococci (CMR) (2014) — doi:10.1128/CMR.00109-13

This page is the text version, generated at build time. The 3D anatomical atlas requires JavaScript.