Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Coagulase-negative staphylococci (CoNS) — Coagulase-negative staphylococci (group) — incl. S. lugdunensis

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 5 November 2026 · Methodology

Staphylococcaceae · Gram-positive

Les SCN (S. epidermidis, S. haemolyticus, S. capitis, S. warneri, S. saprophyticus) sont la 1ère cause de bactériémie nosocomiale mais représentent aussi la 1ère cause de contamination d'hémoculture. Règle clinique : SCN significatif si ≥2 flacons positifs sur des sites différents ; un seul flacon positif chez un patient porteur de cathéter : prélever d'autres hémocultures, par le cathéter suspect et par une veine périphérique, avant toute antibiothérapie et/ou ablation du cathéter, pour s'assurer d'une bactériémie vraie et de l'origine du cathéter (IDSA 2009, rec. 38). À noter pour S. lugdunensis : il se comporte comme S. aureus (endocardite agressive, destruction valvulaire rapide) — ETT/ETO recommandée, prise en charge décrite comme celle de S. aureus. S. saprophyticus : 2ème cause d'IU de la femme jeune sexuellement active — traitement uniquement si symptomatique.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Coagulase-negative staphylococci (CoNS) are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Heart / Endocardium	High tropism	Evidence B	3	not recorded
Skin	High tropism	Evidence B	2	not recorded
Urinary system / Bladder	Moderate tropism	Evidence B	2	not recorded
Meninges (méningite post-neurochirurgicale)	Moderate tropism	Evidence B	2	not recorded
Eye	Moderate tropism	Evidence A	2	not recorded
Bones / Joints	Moderate tropism	Evidence B	2	not recorded

Spread routes recorded: 0 of 6 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Sources

• Frank KL, del Pozo JL & Patel R — Staphylococcus lugdunensis (2008) — doi:10.1128/CMR.00036-07
• ESC Guidelines for the management of endocarditis (Delgado V et al.) (2023) — doi:10.1093/eurheartj/ehad193
• Becker K et al. — Coagulase-negative staphylococci (CMR) (2014) — doi:10.1128/CMR.00109-13
• IDSA — Management of Intravascular Catheter-Related Infections Guidelines (2009) — doi:10.1086/599376
• IDSA — Diagnosis, Prevention and Treatment of Catheter-Associated UTI (CID) (2010) — doi:10.1086/650482
• Endophthalmitis Vitrectomy Study Group — Results of the Endophthalmitis Vitrectomy Study (Arch Ophthalmol) (1995) — doi:10.1001/archopht.1995.01100120009001
• Osmon DR et al. — IDSA Diagnosis and Management of Prosthetic Joint Infection (2012) — doi:10.1093/cid/cis803
• HAS — Prothèse de hanche ou de genou : diagnostic et prise en charge de l'infection dans le mois suivant l'implantation (RBP, mars 2014) (2014) — https://www.has-sante.fr/jcms/c_1228574/fr/prothese-de-hanche-ou-de-genou-diagnostic-et-prise-en-charge-de-l-infection-dans-le-mois-suivant-l-implantation

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