Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Plasmodium falciparum — Malaria

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 26 October 2026 · Methodology

Plasmodiidae · Parasite

Toute fièvre au retour d'une zone d'endémie palustre = frottis + goutte épaisse sans délai (± TDR). Le paludisme grave à P. falciparum engage le pronostic vital et est traité par artésunate IV (Dondorp 2010). Outil informatif — la prise en charge relève d'un avis spécialisé en médecine tropicale / infectiologie.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Plasmodium falciparum are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Central nervous system	High tropism	Evidence B	2	hematogenous
Kidney	Moderate tropism	Evidence B	2	hematogenous
Lung	Moderate tropism	Evidence B	2	hematogenous
Spleen	High tropism	Evidence B	2	hematogenous

Described portals of entry

• Skin

Spread routes recorded: 4 of 4 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Sources

• White NJ et al. — Malaria (Seminar) (2014) — doi:10.1016/S0140-6736(13)60024-0
• WHO — Guidelines for malaria (2023) — https://www.who.int/publications/i/item/guidelines-for-malaria

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