Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Mucorales (Mucor, Rhizopus, Lichtheimia) — Mucormycosis

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 26 October 2026 · Methodology

Mucorales (ordre) · Mould

Infection fongique à pronostic vital engagé — mortalité très élevée, variable selon la localisation. Champignons filamenteux à angles droits (vs Aspergillus à 45°). Facteurs de risque : (1) diabète acidocétosique (forme rhino-cérébrale ++) ; (2) hémopathie + neutropénie profonde (forme pulmonaire) ; (3) deferoxamine (chélateur du fer utilisé en dialyse — facteur de risque majeur). TRAITEMENT : amphotéricine B liposomale IV + débridement chirurgical URGENT (résection tissulaire large). Isavuconazole ou posaconazole en relais oral. Voriconazole INEFFICACE (différence majeure avec Aspergillus). Réversion de l'immunodépression si possible.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Mucorales (Mucor, Rhizopus, Lichtheimia) are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Paranasal sinuses (porte d'entrée ROCM)	High tropism	Evidence B	2	contiguous
Central nervous system — Mucormycose rhinocérébrale	High tropism	Evidence B	1	contiguous
Lung	High tropism	Evidence B	1	direct
Skin — Mucormycose cutanée	Moderate tropism	Evidence B	2	direct

Described portals of entry

• Lung
• Skin

Spread routes recorded: 4 of 4 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Sources

• Roden MM et al. — Epidemiology and outcome of zygomycosis: review of 929 cases (CID) (2005) — doi:10.1086/432579
• Cornely OA et al. — ECMM/ISHAM Mucormycosis Epidemiology and Clinical Guidelines (2019) — doi:10.1016/S1473-3099(19)30312-3

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