Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Leptospira interrogans — Leptospirosis

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 10 October 2026 · Methodology

Leptospiraceae · Spirochaete

Zoonose aquatique (rongeurs, bétail) : contamination par eau/sol souillé d'urine animale. Deux phases : (1) leptospirémique (J1-J7) : syndrome grippal + myalgies + conjonctivite ; (2) phase immune (J8-J30) : complications viscérales. Maladie de Weil : triade ictère + insuffisance rénale + troubles hémorragiques. ATB : doxycycline ou azithromycine (forme précoce de l'adulte ; azithromycine ou amoxicilline chez la femme enceinte et l'enfant), pénicilline G IV, ampicilline ou ceftriaxone (forme sévère).

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Leptospira interrogans are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Kidney	High tropism	Evidence C	1	hematogenous
Liver / Bile duct	High tropism	Evidence C	1	hematogenous
Lung	Moderate tropism	Evidence C	1	not recorded
Eye	Moderate tropism	Evidence C	1	not recorded

Described portals of entry

• Skin

Spread routes recorded: 2 of 4 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Sources

• Haake DA & Levett PN — Leptospirosis in humans (2015) — doi:10.1007/978-3-662-45059-8_5

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