Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Cryptococcus neoformans — Cryptococcosis

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 30 October 2026 · Methodology

Cryptococcaceae · Yeast

Cryptococcose = infection opportuniste majeure du VIH (CD4 < 100/mm³) mais aussi des greffés d'organe solide et sous anti-calcineurines. Ag cryptococcique LCR et sérique : excellente sensibilité/spécificité. ATB : amphotéricine B liposomale + flucytosine (induction (duration not verified)) puis fluconazole (consolidation + maintenance (duration not verified) chez le VIH) — see cited source. Chez le VIH, pas d'initiation immédiate ou très précoce des antirétroviraux ; en ressources optimales, délai individualisé selon l'évolution clinique et la pression intracrânienne ; duration not verified en accès limité (ECMM/ISHAM/ASM 2024) — see cited source. Pression intracrânienne : ponctions décompressives répétées si HTIC.

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Cryptococcus neoformans are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Meninges	High tropism	Evidence A	3	hematogenous
Lung	High tropism	Evidence B	2	direct
Central nervous system	Moderate tropism	Evidence B	2	not recorded

Described portals of entry

• Lung

Spread routes recorded: 2 of 3 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Associated syndromes

• Brain abscess

Sources

• WHO — Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV (2022) — https://www.who.int/publications/i/item/9789240052178
• Molloy SF et al. — Antifungal combinations for treatment of cryptococcal meningitis (NEJM) (2018) — doi:10.1056/NEJMoa1710922
• Perfect JR et al. — IDSA Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update (CID) (2010) — doi:10.1086/649858

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