Educational resource · Not a medical device · Infectious diseases review in progress · Does not replace clinical judgement

Bartonella spp. — Bartonella infections

Review by an infectious diseases specialist in progress · edited by a physician, AI-assisted writing · level of evidence computed from the source type · page as of 30 October 2026 · Methodology

Bartonellaceae · Gram stain not contributive

Bartonella henselae (maladie des griffes du chat, angiomatose bacillaire chez le VIH) + B. quintana (fièvre des tranchées, angiomatose bacillaire) + B. bacilliformis (maladie de Carrión). Endocardite à Bartonella = cause reconnue d'endocardite à hémocultures négatives (Raoult D 1996). Sérologie Bartonella recommandée devant endocardite à hémocultures négatives. ATB : azithromycine (griffes du chat), doxycycline ± rifampicine (formes sévères/EI).

Scope: dosing as described in the cited guidelines (French or international context, stated by the source), for adults with normal renal function unless stated on the line. No renal or hepatic, paediatric or pregnancy adjustment is provided systematically. These regimens have not been reviewed by any infectious-disease specialist to date.

Documented organ tropism

Organs where foci of Bartonella spp. are described in the cited literature. The reported frequency is not an individual probability.

Organ	Tropism	Level of evidence	Sources	Spread route
Lymph nodes	High tropism	Evidence C	1	lymphatic
Heart / Endocardium	Moderate tropism	Evidence B	2	hematogenous
Liver / Bile duct (péliose)	Moderate tropism	Evidence B	2	not recorded
Skin	Moderate tropism	Evidence B	2	not recorded
Eye — Neurorétinite / Syndrome de Parinaud	Rare tropism	Evidence C	2	hematogenous

Described portals of entry

• Skin

Spread routes recorded: 3 of 5 documented foci A focus without a route is not a focus without spread: the route is simply not recorded.

Sources

• Rolain JM et al. — Recommendations for treatment of human infections caused by Bartonella species (Antimicrob Agents Chemother) (2004) — doi:10.1128/AAC.48.6.1921-1933.2004
• ESC Guidelines for the management of endocarditis (Delgado V et al.) (2023) — doi:10.1093/eurheartj/ehad193
• NIH / CDC / HIVMA-IDSA — Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV (2019) — https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections
• Cunningham ET & Koehler JE — Ocular bartonellosis (Am J Ophthalmol) (2000) — doi:10.1016/S0002-9394(00)00573-0
• Reed JB et al. — Bartonella henselae neuroretinitis in cat scratch disease (Ophthalmology) (1998) — doi:10.1016/s0161-6420(98)93028-7

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